个人简介
为广东省珠江学者特聘教授，广东省教学名师，广东省教学团队与课程思政示范教学团队负责人，主持国家级一流在线开放课程和精品资源共享课。南方医科大学“教学名师”、“本科教学优秀教师”与“南医优秀教师”。以第一完成人获广东省教育教学成果一等奖、中华医学科技奖三等奖、广东省医学科技奖二等奖、广东省科技进步三等奖各1项，国家发明专利2项。主持WHO/TDR项目1项，国家自然科学基金重点项目1项，面上类项目9项，国家科技部重点研发子课题1项，广东省自然科学基金重点项目与广州市科技计划重点项目各1项及其它省级以上课题15项。以第一作者、通讯作者身份在Nature Communication, Science China -Life Sciences,mBio,Plos Neglected Tropical Diseases，ACS Sensors. 等刊物发表论文80余篇。获校级教学成果一等奖2项,一作或通讯作者发表教学SCI论文1篇、中国高等医学教育等刊物论文8篇。获第二届全国高校（医学类）微课教学比赛二等奖及风采奖，近五年5次获得校级教学优秀一等奖；主持国家与省级质量工程项目9项，省部级教改课题8项；主编出版人民卫生出版社、中国医药科技出版社、科学出版社、郑州大学出版社全英教材等重点规划教材等6部，副主编出版高等教育出版社、北京大学医学出版社重点规划教材3部。
研究领域
主要研究方向病原-宿主互作、蚊媒传染病防控。近十年主要承担的科研项目有：
1.国家自然科学基金委员会，重点项目，82330072，弓形虫感染激活小胶质细胞导致小鼠神经精神异常的机制研究，2024.01-2028.12，220万元，在研，主持
2.广东省自然科学基金委员会，面上项目，弓形虫慢性感染小鼠通过肠脑轴引发神经精神异常症状机制的研究， 2024.01-2026.12，15.0万元，在研，主持
3.国家自然科学基金委员会，面上项目，82272364，弓形虫顶质体膜蛋白FtsH1参与虫体脂代谢及免疫逃避的机制研究，2023.01-2026.12，52.0万元，在研，主持
4.中央军委后勤保障部，生物安全重点课题，23SWAQ15，****的分子御机制研究 2023.9-2025.12，60.0万元，在研，主持
5.广东省教育厅，校企联合实验室，传染病病原鉴定与传播风险评估联合实验室，2024.01-2027.12，20.0万元，在研，主持
6.国家自然科学基金委员会，面上项目，81971954，弓形虫DNA甲基转移酶在速/缓殖子相互转化过程中的作用机制研究，2020.01-2023.12，55.0万元，在研，主持
7. 彭鸿娟，广东省自然科学基金，2023A1515011733，宿主波形蛋白Vimentin促进弓形虫入侵血脑屏障致脑损伤机制的研究，2023.01.01-2025.12.31，10.0万元，在研，主持
8.广州市科技局，广州市重点实验室基础研究计划项目（202102100001），40.0万元，结题，合作主持
9.广州市科技局，科学研究计划重点项目，201904020011，弓形虫ROP18劫持宿主细胞泛素系统实现免疫逃避机制的研究，2019.04-2022.03，200万元，结题，主持
10.广东省科技厅，国际科技合作，2018A050506038，应用BioID方法筛选弓形虫毒力因子ROP18的互作蛋白组解析其抑制凋亡发生的机制，2018.12-2020.12，50万元, 结题，主持
11.国家自然科学基金委员会，面上项目，81772217，弓形虫ROP18结合宿主NMI抑制IFN‐γ依赖抗感染机制的研究，2018.01-2021.12，55.0万元，结题，主持
12.国家科技部，重点研发专项，2017YFD0500400，子课题“畜禽重要胞内寄生原虫的寄生与免疫机制研究”， 2017.07-2021.07， 70.0万元，在研，主持
13.国家自然科学基金委员会，海外及港澳学者合作研究，8182800002，弓形虫ROP18在宿主生理活性下的互作蛋白组筛选及其调控宿主细胞凋亡机制的研究，2019.01-2020.12, 18.0万元，在研，与新加坡国立大学Cynthia Y. He合作主持
14.广州市科技局，健康医疗协同创新重大专项（201604020011）分题，“新发突发烈性传染病防控及治疗新技术研究”, 2016.08-2018.08, 108.0万元, 已结题，唐时幸/彭鸿娟 主持
15.国家自然科学基金委员会，面上项目，81572012，宿主细胞互作蛋白介导的弓形虫ROP18毒力机制研究, 2016.1-2019.12，55.0万元，已结题，主持
16.广东省科技厅，自然科学基金重点项目，2016A030311025，宿主细胞互作蛋白介导的弓形虫ROP18毒力机制研究，2016.06-2019.05，30.0万元，已结题，主持
17.广东省教育厅，珠江学者（特聘教授），2014年，流行病与统计学—传染病预防与控制, 2016.06-2019.05，100万元，已结题，主持
18.国家自然科学基金委员会，面上项目，81271866，宿主细胞信号水平弓形虫感染机制的研究， 2013.1-2016.12，70.0万元，已结题，主持
19.广东省教育厅，广东省高等学校人才引进专项资金（2011-67），弓形虫感染与宿主细胞信号转导的变化，2012.01-2014.12, 25.0万元，已结题，主持
20.广东省科技厅，科技攻关项目，2011B010500003，一种高效安全重组蚊虫真菌杀虫剂的开发与应用，2012.01-2013.12，8.0万，已结题，主持
21.国家自然科学基金委员会，面上项目，81071377，宿主细胞RacGTP酶及其相关信号通路在弓形虫入侵过程中的作用机制研究，2011.01-2013.12，32.0万元，已结题，主持
22.广东省卫生厅，2011-2014年全国农村卫生环境监测横向课题，K1051022，2011.01-2014.12, 100.0万元，已结题，主持
23.国家自然科学基金委员会，重点项目，31030066，弓形虫机会性致病的调控机制研究, 2011.1-2014.12, 212.0万元，已结题，参与
个人成果
近年来第一作者或通讯作者发表的代表性文章
1．Chen, M., Koszti, S.G., Bonavoglia, A. Bohumil Maco, Olivier von Rohr, Peng H*, Dominique Soldati-Favre* ,Joachim Kloehn*. Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle. Nat Commun.2025. 16: 2095. https://doi.org/10.1038/s41467-025-57302-x
2．Wang C, Sun P, Jia Y, Tang X, Liu X, Suo X, Peng H*. Protein disulfide isomerase PDI8 is indispensable for parasite growth and associated with secretory protein processing in Toxoplasma gondii. mBio. 2024 Sep 11;15(9):e0205124. doi: 10.1128/mbio.02051-24.
3．Chen J#, Zhang C#, Yang Z, Wu W, Zou W, Xin Z, Zheng S, Liu R, Yang L, Peng H*. Intestinal microbiota imbalance resulted by anti-Toxoplasma gondii immune responses aggravate gut and brain injury. Parasit Vectors. 2024 Jul 2;17(1):284. doi: 10.1186/s13071-024-06349-8.
4．Wu W, Chen Q, Zou W, Chen J, Zhu D, Yang H, Ouyang L, Liu X, Peng H*. Toxoplasma gondii bradyzoite-specific BAG1 is nonessential for cyst formation due to compensation by other heat-shock proteins. Parasit Vectors. 2024 Jul 30;17(1):322. doi: 10.1186/s13071-024-06339-w.
5．Yang L, Wang B, Yang Z, Zheng S, Xin Z, Wu S, Zou W, Peng H*. Toxoplasma gondii infection positively associated with schizophrenia: Evidences from UK Biobank cohort and case-controlled studies. Journal of Psychiatric Research. 2024 May 9;175:243-250. doi: 10.1016/j.jpsychires.2024.05.025.
6．Yang L, Wang B, Wu S, Yang Z, Xin Z, Zheng S, Zou W, Zhang C, Chen J, Peng H*. Population-based cohort study of Toxoplasma gondii P22 antibody positivity correlation with anxiety. Journal Of Affective Disorders. 2024 Aug 15;359:41-48. doi: 10.1016/j.jad.2024.05.043.
7．Yang Z, Chen J, Zhang C, Peng H*. Pathological Mechanisms Of Glial Cell Activation And Neurodegenerative And Neuropsychiatric Disorders Caused By Toxoplasma gondii Infection. Front. Microbiol. 2024.15:1512233. doi: 10.3389/fmicb.2024.1512233
8．Wei H, Wu S, Mai L, Yang L, Zou W, Peng H*. Cbl-b negatively regulates TLR/MyD88-mediated anti-Toxoplasma gondii immunity. Microbiology Spectrum. 2023 Dec 12;11(6):e0007423. doi: 10.1128/spectrum.00074-23.
9．Chen M, Yang P, Xin Z, Chen J, Zou W, Zhou L, Yang L, Peng J, Peng H*. Toxoplasma gondii gra5 deletion mutant protects hosts against Toxoplasma gondii infection and breast tumors. Frontiers in Immunology. 2023 Jun 23;14:1173379. doi: 10.3389/fimmu.2023.1173379. .
10．Chen J, Deng S, Peng H*. Insect-specific Viruses Used in Bio-control of Mosquito-borne Diseases. Interdiciplinary Medicine. 2023, e20220001. https://doi.org/10.1002/INMD.20220001
11．Xin ZX, Chen JT,Peng HJ*. Advances in Spectral Techniques for Detection of Pathogenic Microorganisms. Zoonoses. 2022; 2:8. DOI 10.15212/ZOONOSES-2021-0027
12．Chen J, Liao W, Peng H*. Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth. Frontiers in Cellular and Infection Microbiology. 2022 Aug 31;12:959300. doi: 10.3389/fcimb.2022.959300.
13．Liu F, Hu H, Deng M, Xiang Z, Guo Y, Guan X, Li D, Hu Q, Lei W*, Peng H*, Chu J*. A Bright Monomeric Near-Infrared Fluorescent Protein with an Excitation Peak at 633 nm for Labeling Cellular Protein and Reporting Protein-Protein Interaction. ACS Sensors. 2022 Jul 22;7(7):1855-1866. doi: 10.1021/acssensors.2c00286.
14．Chen M #, Yao L #, Zhou L, Yang P, Zou W, Xu L, Li S, Peng HJ*. Toxoplasma gondii ROP18I Inhibits Host Innate Immunity through cGAS-STING Signaling. FASEB Journal. 2022 Feb;36(2):e22171. doi: 10.1096/fj.202101347R.
15．Zhou LJ, Peng J, Chen M, Yao LJ, Zou WH, He CY, Peng HJ*. Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity. iScience. 2021 Nov 26;24(12):103514. doi: 10.1016/j.isci.2021.103514.
16．Jiang D, Wu S; Xu L, Xie G, Peng H*. Anti-Infection Roles of mir155-5p Packaged in Exosomes Secreted by Dendritic Cells Infected with Toxoplasma gondii. Parasites & Vectors. 2022 Jan 6;15(1):3. DOI: 10.1186/s13071-021-05003-x
17．Xu L, Yao L, Jiang D, Zhou L, Chen M , Liao W, Zou W, Peng H*. A uracil auxotroph Toxoplasma gondii exerting immunomodulation to inhibit breast cancer growth and metastasis. Parasites & Vectors. 2021 Dec 11;14(1):601. DOI: 10.1186/s13071-021-05032-6
18．Yao LJ, Xu LQ, Zhou LJ, Wu SZ, Zou WH, Chen M, Chen JT, Peng HJ*. Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21for Immune Escape. Frontiers in Cell and Developmental Biology. 2021, May 26; 9:685913. doi: 10.3389/fcell.2021.685913.
19．Kong L, Peng H*. Current epidemic situation of human toxocariasis in China.Adv Parasitol. 2020;109:433-448. doi: 10.1016/bs.apar.2020.01.016.
20．Kong L#, Jiang D#, He C, Xia J, Wei H, Zhou L, Peng H*.TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection.Parasites & Vectors. 2020 Aug 7;13(1):400. doi: 10.1186/s13071-020-04251-7. PMID: 32767999;
21．Xia J, Blank ML, Zhou LJ, Wu SZ, Peng HJ*, Boyle JP*. Strain-specific disruption of interferon-stimulated N-myc and STAT interactor (NMI) function by Toxoplasma gondii type I ROP18 in human cells. Parasitology. 2020 Nov;147(13):1433-1442. doi: 10.1017/S0031182020001249. Epub 2020 Jul 30.
22．He C，Xu MZ， Pan S，Wang H， Peng HJ*，Liu ZZ *. iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress. Frontiers in Cellular and Infection Microbiology, 2020 Nov 26;10:586466. doi: 10.3389/fcimb.2020.586466. PMID: 33363051;
23．Deng SQ, Peng HJ*. Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China. Journal of Clinical Medicine. Journal of Clinical Medicine. 2020 Feb 20;9(2):575. doi: 10.3390/jcm9020575.
24．Deng SQ, Yang X, Wei Y, Chen JT, Wang XJ, Peng HJ*. A Review on Dengue Vaccine Development.Vaccines. 2020 Feb 2;8(1):63. doi: 10.3390/vaccines8010063.
25．Xia J, Kong L, Zhou LJ, Wu SZ, Yao LJ, He C, He CY, Peng HJ*. Genome-Wide Bimolecular Fluorescence Complementation- Based Proteomic Analysis of Toxoplasma gondii ROP18’s Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis. Frontiers in Immunology. 2018 Feb 5;9:61. doi: 10.3389/fimmu.2018.00061.
26．Wu S#, Wei H#, Jiang D, Li S, Zou W, Peng HJ* . Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii Infection. Frontiers in Cellular and Infection Microbiology, 2020 Jan 22;9:460. doi: 10.3389/fcimb.2019.00460.
27．Li DL, Zou WH, Deng SQ, Peng HJ*. Analysis of the Dierential Exosomal miRNAs of DC2.4 Dendritic Cells Induced by Toxoplasma gondii Infection. International Journal Of Molecular Sciences. 2019 Nov 5; 20(21): 5506. doi: 10.3390/ijms20215506.
28．Wei H, Zhou L, Wu S, Li D, Deng S, Peng H*. Host cell Rac1 GTPase facilitates Toxoplasma gondii invasion. Science China-Life Science. 2020 Apr; 63(4):610-612. doi: 10.1007/s11427-019-9564-0.
29．Zhou LJ, Chen M, Puthiyakunnon S, He C, Xia J, He C, Deng SQ，Peng H*. Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1. Parasit Vectors. 2019 Jun 4;12(1):284. doi: 10.1186/s13071-019-3529-1.
30．He C, Kong L, Puthiyakunnon S, Wei HX, Zhou LJ, Peng H-J*. iTRAQ-based phosphoproteomic analysis reveals host cell's specific responses to Toxoplasma gondii at the phases of invasion and prior to egress. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):202-212. doi: 10.1016/j.bbapap.2018.12.004.
31．Deng SQ, Zou WH, Li DL, Chen JT, Huang Q, Zhou LJ, Tian XX, Chen YJ, Peng HJ*. Expression of Bacillus thuringiensis toxin Cyt2Ba in the entomopathogenic fungus Beauveria bassiana increases its virulence towards Aedes mosquitoes. PLoS Neglected Tropical Diseases. 2019 Jul 15;13(7):e0007590. doi: 10.1371/journal.pntd.0007590.
32．Deng SQ, Chen JT, Li WW, Chen M, Peng HJ. Application of the Scorpion Neurotoxin AaIT against Insect Pests. International Journal Of Molecular Sciences. 2019 Jul 15;20(14):3467. doi: 10.3390/ijms20143467.
33．Deng S, Huang Q, Wei H, Zhou L, Yao L, Li D, Wu S, Chen J, Peng H*. Beauveria bassiana infection reduces the vectorial capacity of Aedes albopictus for the Zika virus. Journal of Pest Science. 2019, 92（2）:781-789.
34．He C, Kong L, Zhou L, Xia J, Wei H, Liu M, Peng H* .Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Its hosphorylation Is Partly Regulated by TgROP18 Interaction. International Journal of Biological Sciences. 2017 Sep 5;13(9):1126-1137. doi: 10.7150/ijbs.21247.
35．Wei H, Jiang S, Chen L, He C, Wu S, Peng H*. Characterization of Cytosine Methylation and the DNA Methyltransferases of Toxoplasma gondii.International Journal of Biological Sciences. 2017 Mar 11;13(4):458-470. doi: 10.7150/ijbs.18644.
36．He C, Chen AY, Feng XS, Wei HX, Jiang SC, Xia J, Deng SQ, Wang XJ, Peng HJ* Phosphoproteome of Toxoplasma gondii Infected Host Cells Reveals Specific Cellular Processes Predominating in Different Phases of Infection.American Journal of Tropical Medicine and Hygien. 2017 Jul;97(1):236-244. doi: 10.4269/ajtmh.16-0901.
37．Na RH, Zhu GH, Luo JX, Meng XJ, Cui L, Peng HJ*, Chen XG*, Gomez – Cambronero J. Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells. BMC Microbiology. 2013 May 30;13:125. doi: 10.1186/1471-2180-13-125.
38．Xia J, Cheng XY, Wang XJ, Peng HJ* Association between Toxoplasma gondii types and outcomes of human infection: a review and meta-analysis. Acta Microbiologica et Immunologica Hungarica. 2017 Sep 1;64(3):229-244. doi: 10.1556/030.64.2017.016.
39．Shen SQ, Wei HX, Fu YH, Zhang H, Mo QY, Wang XJ, Deng SQ, Zhao W, Liu Y, Feng XS, Chen W, Peng HJ*. Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014. Scientific Reports. 2015 Nov 23;5:16913. doi: 10.1038/srep16913.
40．Zhou LJ，Xia J，Wei HX，Liu XJ，Peng HJ* Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.Parasitology Research. 2017 Feb;116(2):781-788. doi: 10.1007/s00436-016-5353-2.
41．Wang XJ, Jiang SC, Wei HX, Deng SQ, He C, Peng HJ*. The Differential Expression and Possible Function of Long Noncoding RNAs in Liver Cells Infected by Dengue Virus. American Journal of Tropical Medicine and Hygiene. 2017 Dec;97(6):1904-1912. doi: 10.4269/ajtmh.17-0307.
42．Wang XJ, Wei HX, Jiang SC, He C, Xu XJ, Peng HJ*. Evaluation of aminotransferase abnormality in dengue patients: A meta analysis. Acta Tropica. 2016 Apr;156:130-6. doi: 10.1016/j.actatropica.2015.12.013.
43．Deng SQ, Cai QD, Deng MZ, Huang Q, Peng HJ*. Scorpion neurotoxin AaIT-expressing Beauveria bassiana enhances the virulence against Aedes albopictur mosquitoes. AMB Express. 2017 Dec;7(1):121. doi: 10.1186/s13568-017-0422-1.
44．Huang Q, Hu L, Liao QB, Xia J, Wang QR, Peng HJ*. Spatiotemporal analysis of the malaria epidemic in mainland China, 2004-2014. American Journal of Tropical Medicine and Hygien.. 2017 Aug;97(2):504-513. doi: 10.4269/ajtmh.16-0711.
45．Zhang H. He Z, Zeng W*, Peng HJ*. Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors.Canadian Journal of Infectious Diseases and Medical Microbiology, 17:1671607. 2017; 2017:1671607. doi: 10.1155/2017/1671607.
46．Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ*(2013) Distribution of Tick-borne Diseases in China.Parasites Vectors. 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899;
47．Peng H-J#,Henkels KM#, Mahankali M, Dinauer MC. Gomez-Cambronero J.Evidence For Two Crib Domains In Phospholipase D2 (Pld2) That The Enzyme Uses to Specifically Bind to The Small GTPase Rac2. Journal of Biological Chemistry 286(18): 16308-20
48．Peng H-J#, Henkels KM#, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J (2011) The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Molecular and Cellular Biology. 2011; 31(11):2227-40
49．Peng H-J#，Chen X-G#，Lindsay DS*，A Review: Competence, Compromise, And Concomitance-Reaction Of The Host Cell To Toxoplasma Gondii Infection And Development. Journal of Parasitology，2011.8.01，97（4）：620~628
50．Peng H-J#，Zhang C(#)，Wang C-M，Chen X-G*，Current Status and Challenge of Human Parasitology Teaching in China. Pathogen and Global Health，2012.12.11，106（7）：386~390
51．Peng H-J，Lai H-B，Zhang Q-L，Xu B-Y，Zhang H，Liu W-H，Zhao W，Zhou Y-P，Zhong X-G，Jiang S，Duan J-H，Yan G-Y，He J-F(*)，Chen, Xiao-Guang，A local outbreak of dengue caused by an imported case in Dongguan China. BMC Public Health，2012.1.26，12（1）:83
获得学术奖励
1.彭鸿娟，刘全，袁子国，朱兴全，范泉水. 弓形虫病流行特征、致病机制与防治基础研究. 中华医学科技奖三等奖（2021.03）, 排名1.
2.彭鸿娟，刘全，袁子国，朱兴全，范泉水，张秀香，王泽东、何成、魏海霞。弓形虫病流行特征、致病机制与防治基础研究. 广东省医学科技奖二等奖（2021.01），排名1
3.日本血吸虫病新基因的发现鉴定、及优势抗原的筛选及应用，广东省科学技术奖三等奖（2005年5月），排名1.
4.弓形虫主要表面抗原的基因克隆、表达及其在诊断和疫苗研制中的应用。广东省科学技术奖二等奖（2004年5月），排名9.
专利/Patents:
1.国家发明专利名称：鼠源弓形虫Ftsh1单克隆抗体及其应用; 发明人：彭鸿娟，邹伟浩，郑佳佳，叶茵，黄佳雯，李佳汶。专利号：202210377381.X。专利授权时间：2023年5月8日
2.国家发明专利名称：鼠源弓形虫Ftsh1单克隆抗体及其应用; 发明人：彭鸿娟，吴蔚玲，陈棋棋，郑书雨。
3.国家发明专利名称：一种生物杀虫剂筛选模型及其制备方法和应用；发明人：彭鸿娟，陈晓光，顾金保；专利号：ZL 2006 1 0122057.4；专利授权时间：2010.07；专利申请国：中国
4.国家发明专利名称：一种毒杀蚊幼虫的双价重组球孢白僵菌及其制备方法；发明人：彭鸿娟、廖启彬, 等。专利号：201510176572X; 专利授权时间：2018.05；专利申请国：中国
专著/Books：
1.沈继龙，伦照荣(主编), 彭鸿娟, 等(副主编). 弓形虫与弓形虫病. 人民卫生出版社. ISBN: 9787117350594. 2023年10月出版。
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